The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2023
Filed:
Apr. 10, 2019
Applicant:
The Regents of the University of California, Santa Cruz, CA (US);
Inventors:
Seth Rubin, Santa Cruz, CA (US);
Keelan Guiley, Santa Cruz, CA (US);
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C07K 14/47 (2006.01); C12Q 1/48 (2006.01);
U.S. Cl.
CPC ...
C12N 9/12 (2013.01); C07K 14/4738 (2013.01); C12Q 1/485 (2013.01); C12Y 207/11022 (2013.01); G01N 2440/14 (2013.01); G01N 2500/02 (2013.01);
Abstract
The disclosure provides polypeptides comprising an engineered p27, or a fragment thereof. Such polypeptides may be used to form trimeric protein complexes with a cyclin-dependent kinase 4 (Cdk4) (or a variant thereof) or Cdk6 (or a variant thereof), and a cyclin D (CycD) or a variant thereof.