The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2023
Filed:
Jun. 18, 2021
Zhejiang Zhenyuan Biotech Co., Ltd., Shaoxing, CN;
Tianjin University of Science and Technology, Tianjin, CN;
Xixian Xie, Tianjin, CN;
Weiming Fan, Shaoxing, CN;
Heyun Wu, Tianjin, CN;
Wei Jiang, Shaoxing, CN;
Daoguang Tian, Tianjin, CN;
Yanna Chen, Shaoxing, CN;
Yue Zhang, Tianjin, CN;
Jianqing Tu, Shaoxing, CN;
ZHEJIANG ZHENYUAN BIOTECH CO., LTD., Shaoxing, CN;
Tianjin University of Science and Technology, Tianjin, CN;
Abstract
A genetically engineered bacterium includes a genome of theand a mutant encoding gene hisG* of aATP phosphoribosyl transferase HisG on the genome, and the gene hisG* is strongly expressed to enhance activity of a key enzyme HisG for histidine synthesis. The gene hisG* has a nucleotide sequence as shown in SEQ ID NO: 1; a copy number of histidine operon genes hisDBCHAFI of theis further increased on the genome to enhance a terminal synthetic route of histidine; an encoding gene lysE from an arginine/lysine transportprotein of theis further integrated to the genome and strongly expressed to promote the intracellular histidine secrete to the extracellular space; and an encoding gene rocG of glutamate dehydrogenase ofis further integrated to the genome and strongly expressed to promote generation of histidine.