The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2023
Filed:
Jun. 26, 2018
Applicant:
Mackay Memorial Hospital, Taipei, TW;
Inventors:
Assignee:
MACKAY MEMORIAL HOSPTAL, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0775 (2010.01); C12N 5/073 (2010.01); C12N 15/113 (2010.01); A61K 38/17 (2006.01); A61K 31/713 (2006.01); A61K 9/50 (2006.01); C12N 15/11 (2006.01); A61K 41/10 (2020.01); A61K 35/28 (2015.01); A61K 41/17 (2020.01); A61P 35/00 (2006.01); A61P 9/00 (2006.01); A61P 29/00 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0665 (2013.01); A61K 9/50 (2013.01); A61K 9/5068 (2013.01); A61K 31/713 (2013.01); A61K 35/28 (2013.01); A61K 38/179 (2013.01); A61K 41/10 (2020.01); A61K 41/17 (2020.01); C12N 5/0605 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); A61P 9/00 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C12N 2310/141 (2013.01); C12N 2320/32 (2013.01); C12N 2500/02 (2013.01); C12N 2500/30 (2013.01); C12N 2501/65 (2013.01);
Abstract
Disclosed herein is a formulation comprising an extracellular vesicle (EV), and a therapeutic active agent induced or embedded in the EV. According to preferred embodiments of the present disclosure, the EV is isolated from umbilical cord mesenchymal stem cells, and the active agent may be a growth factor, an immune-modulating agent, a small molecule, an siRNA, cDNA or a plant ingredient; for example, curcumin. Also disclosed herein are methods for producing the present formulation, and uses of the present formulation in the treatment of various diseases.