The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2023
Filed:
Oct. 11, 2019
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Benjamin Cravatt, La Jolla, CA (US);
Vincent Crowley, San Diego, CA (US);
Xiaoyu Zhang, San Diego, CA (US);
Assignee:
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 495/14 (2006.01); C07B 59/00 (2006.01);
U.S. Cl.
CPC ...
C07D 495/14 (2013.01); C07B 59/002 (2013.01); C07B 2200/05 (2013.01);
Abstract
Disclosed herein are methods and compounds for inducing DDB1- and CUL4-associated factor 16 (DCAF16)-mediated protein degradation in mammalian cells. In some embodiments, also disclosed herein are methods of modulating the substrate selectivity of a DCAF16-CUL4-RBX1-DDB1 complex (CRL4) for modulating protein degradation.