The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 04, 2023

Filed:

Dec. 01, 2022
Applicant:

Pfizer Inc., New York, NY (US);

Inventors:

Shelley Allen, Niwot, CO (US);

Patrick Michael Doerner Barbour, Westminster, CO (US);

James Francis Blake, Longmont, CO (US);

Sydney Taylor Blanche, Longmont, CO (US);

Mark Laurence Boys, Lyons, CO (US);

Wesley Dewitt Clark, Gales Ferry, CT (US);

Connor James Cowdrey, Longmont, CO (US);

Joshua Ryan Dahlke, Longmont, CO (US);

Alex Andrew Kellum, Boulder, CO (US);

Ellen Margaret Knapp, Lafayette, CO (US);

David Austin Moreno, Centennial, CO (US);

Jacob Matthew O'Leary, Boston, MA (US);

Li Ren, Superior, CO (US);

Faith Elizabeth Witkos, Attleboro, MA (US);

Jennifer Lynn Fulton, Longmont, CO (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 35/00 (2006.01); A61K 31/4375 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/4375 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01);
Abstract

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, wherein R, R, Rand Rare as defined herein. The invention further relates to pharmaceutical compositions comprising such compounds and salts, and to methods and uses of such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer, in a subject in need thereof. The invention further relates to solid forms of 8-((2-fluoro-4-(methylthio)phenyl)amino)-2-(2-hydroxyethoxy)-7-methyl-3,4-dihydro-2,7-naphthyridine-1,6(2H,7H)-dione.


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