The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 04, 2023

Filed:

Aug. 30, 2022
Applicant:

Illumina, Inc., San Diego, CA (US);

Inventors:

Ali Agah, Menlo Park, CA (US);

Aathavan Karunakaran, Berkeley, CA (US);

Tarun Khurana, Fremont, CA (US);

Stanley Hong, Palo Alto, CA (US);

Merek Siu, Alameda, CA (US);

Arvin Emadi, San Jose, CA (US);

Craig Ciesla, Mountain View, CA (US);

Assignee:

ILLUMINA, INC., San Diego, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B01L 3/00 (2006.01); G11C 13/02 (2006.01); B01J 19/00 (2006.01); C12Q 1/6874 (2018.01); C12N 15/09 (2006.01);
U.S. Cl.
CPC ...
B01L 3/502715 (2013.01); B01J 19/0046 (2013.01); B01L 3/502707 (2013.01); B01L 3/502738 (2013.01); G11C 13/02 (2013.01); B01J 2219/00711 (2013.01); B01J 2219/00713 (2013.01); B01J 2219/00722 (2013.01); B01L 2200/026 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0867 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/0622 (2013.01); B01L 2400/0655 (2013.01); B01L 2400/08 (2013.01); C12N 15/09 (2013.01); C12Q 1/6874 (2013.01);
Abstract

An apparatus includes a flow cell body, a plurality of electrodes, an integrated circuit, and an imaging assembly. The flow cell body defines one or more flow channels and a plurality of wells. Each flow channel is configured to receive a flow of fluid. Each well is fluidically coupled with the corresponding flow channel. Each well is configured to contain at least one polynucleotide. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are operable to effect writing of polynucleotides in the corresponding wells. The integrated circuit is operable to drive selective deposition or activation of selected nucleotides to attach to polynucleotides in the wells to thereby generate polynucleotides representing machine-written data in the wells. The imaging assembly is operable to capture images indicative of one or more nucleotides in a polynucleotide.


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