The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Jun. 12, 2016
Applicant:
Ascendo Biotechnology, Inc., Grand Cayman, KY;
Inventors:
Yen-Ta Lu, Taipei, TW;
Chia-Ming Chang, Taipei, TW;
Tsai-Yin Wei, Changhua County, TW;
I-Fang Tsai, Taipei, TW;
Ling-Chiao Wu, Hsinchu, TW;
Assignee:
Ascendo Biotechnology, Inc., Grand Cayman, KY;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); C07K 14/705 (2006.01); A61K 47/64 (2017.01); A61K 47/59 (2017.01); A61P 37/06 (2006.01); A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61K 39/395 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2845 (2013.01); A61K 38/1774 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/59 (2017.08); A61K 47/643 (2017.08); A61P 37/06 (2018.01); C07K 14/705 (2013.01); C07K 14/70503 (2013.01); A61K 38/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2319/70 (2013.01);
Abstract
A method for reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a composition to a subject in need of such treatments, wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.