The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2023

Filed:

Dec. 15, 2021
Applicant:

Amicus Therapeutics, Inc., Philadelphia, PA (US);

Inventors:

Kamlesh Sheth, North Brunswick, NJ (US);

Sergey Tesler, Monroe, NJ (US);

James Cartwright, Middlesex, GB;

Clive King, Middlesex, GB;

Wendy Cross, Middlesex, GB;

Assignee:

Amicus Therapeutics, inc., Philadelphia, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/46 (2006.01);
U.S. Cl.
CPC ...
C07D 211/46 (2013.01); C07B 2200/13 (2013.01);
Abstract

Provided are methods of producing Active Pharmaceutical Ingredient (API) grade migalastat hydrochloride, and for purifying intermediate grade migalastat hydrochloride. Further provided are methods of producing [(2R,3S,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride (lucerastat hydrochloride) and other 1-deoxygalactonojirimycin compounds, as well as methods of purifying intermediate grade lucerastat hydrochloride and other 1-deoxygalactonojirimycin compounds.


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