The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Mar. 21, 2017
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Hans-Georg Lerchen, Leverkusen, DE;
Anne-Sophie Rebstock, Champagne au Mont d'Or, FR;
Leo Marx, Martigny, CH;
Sarah Anna Liesa Johannes, Düsseldorf, DE;
Beatrix Stelte-Ludwig, Wülfrath, DE;
Lisa Dietz, Wuppertal, DE;
Carsten Terjung, Bochum, DE;
Christoph Mahlert, Wuppertal, DE;
Simone Greven, Dormagen, DE;
Anette Sommer, Berlin, DE;
Sandra Berndt, Hohen Neuendorf, DE;
BAYER PHARMA AKTIENGESELLSCHAFT, Berlin, DE;
Abstract
The invention relates to novel prodrugs or conjugates of the general formula (Ia) in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.