The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
May. 10, 2021
Applicant:
University of Southern California, Los Angeles, CA (US);
Inventors:
Yong Zhang, Los Angeles, CA (US);
Zhefu Dai, Los Angeles, CA (US);
Xiao-Nan Zhang, Los Angeles, CA (US);
Assignee:
University of Southern California, Los Angeles, CA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/68 (2017.01); C12N 9/24 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6815 (2017.08); A61K 47/6807 (2017.08); A61K 47/6851 (2017.08); A61K 47/6889 (2017.08); C07K 16/2851 (2013.01); C12N 9/2497 (2013.01); A61K 2039/505 (2013.01); C07K 2317/90 (2013.01); C07K 2319/00 (2013.01); C12Y 302/02006 (2013.01);
Abstract
Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.