The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 27, 2023

Filed:

Feb. 22, 2018
Applicant:

Bayer Pharma Aktiengesellschaft, Berlin, DE;

Inventor:

Ningshu Liu, Berlin, DE;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); A61K 31/519 (2006.01); A61K 39/00 (2006.01); C07D 243/34 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
A61K 39/39558 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61P 35/00 (2018.01); A61K 47/6801 (2017.08); A61K 2039/545 (2013.01); C07D 243/34 (2013.01);
Abstract

The present invention relates to: * combinations of: component A: one or more 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (A1) or (A2) as defined herein, or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B: anti-Programmed Cell Death Protein 1 (also referred to as 'PD-1' or “CD279” (cluster of differentiation 279)) antibody (anti-PD-1 mAb) as defined herein; in which optionally some or all of the components are in the form of a pharmaceutical formulation which is ready for use to be administered simultaneously, concurrently, separately or sequentially; independently of one another by the oral, intravenous, topical, local installations, intraperitoneal or nasal route; * use of such combinations for the preparation of a medicament for the treatment or prophylaxis of a cancer; and * a kit comprising such a combination.


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