The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Jun. 01, 2021
Applicant:
Albert Einstein College of Medicine, Bronx, NY (US);
Inventors:
Betsy C. Herold, Rowayton, CT (US);
Clare Burn Aschner, Bronx, NY (US);
Assignee:
ALBERT EINSTEIN COLLEGE OF MEDICINE, Bronx, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/245 (2006.01); A61P 31/22 (2006.01); A61K 9/00 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/245 (2013.01); A61K 9/0019 (2013.01); A61P 31/22 (2018.01); C12N 7/00 (2013.01); A61K 2039/54 (2013.01); C12N 2710/16621 (2013.01); C12N 2710/16622 (2013.01); C12N 2710/16634 (2013.01);
Abstract
Methods of vaccinating, immunizing and/or treating a subject against a herpes simplex virus infection or a disease caused by a herpes simplex virus infection comprise administering to the subject an effective amount of a HSV-2 single-cycle virus and an effective amount of a recombinant HSV-2 glycoprotein D, wherein the HSV-2 single-cycle virus comprises HSV-2 having a deletion of glycoprotein D-encoding gene in the genome and the HSV-2 is phenotypically complemented with an HSV-1 glycoprotein D on a lipid bilayer of the HSV-2.