The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Aug. 18, 2020
Spectrum Pharmaceuticals, Inc., Irvine, CA (US);
Hanmi Pharm Co., Ltd., Gyeonggi-do, KR;
Gajanan Bhat, Irvine, CA (US);
Shanta Chawla, Irvine, CA (US);
Jae Hyuk Choi, Gyeonggi-do, KR;
Eun Jung Kim, Gyeonggi-do, KR;
Yu Yon Kim, Gyeonggi-do, KR;
Gyu Hyan Lee, Gyeonggi-do, KR;
Hyesun Han, Gyeonggi-do, KR;
Spectrum Pharmaceuticals, Inc., Irvine, CA (US);
Hanmi Pharm Co., Ltd., , KR;
Abstract
This disclosure provides a method of preventing, alleviating or treating a condition (i.e., neutropenia) in a subject in need thereof, the condition characterized by compromised white blood cell production in the subject. The method includes administering to the subject a therapeutically effective amount of a protein complex on the same day as a chemotherapy regimen, wherein the protein complex is a modified human granulocyte-colony stimulating factor (hG-CSF) covalently linked to an immunoglobulin Fc region via a non-peptidyl polymer. The non-peptidyl polymer is site-specifically linked to an N-terminus of the immunoglobulin Fc region, and the modified hG-CSF comprises substitutions in at least one of Cys17 and Pro65.