The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Nov. 16, 2021
Chemocentryx, Inc., San Carlos, CA (US);
James J. Campbell, San Jose, CA (US);
Karen Ebsworth, San Francisco, CA (US);
Antoni Krasinski, Sunnyvale, CA (US);
Venkat Reddy Mali, Cupertino, CA (US);
Jeffrey Mcmahon, San Francisco, CA (US);
Rajinder Singh, Belmont, CA (US);
Ju Yang, Palo Alto, CA (US);
Chao Yu, Sunnyvale, CA (US);
Penglie Zhang, Foster City, CA (US);
CHEMOCENTRYX, INC., Thousand Oaks, CA (US);
Abstract
The present disclosure provides, inter alia, methods of treating generalized pustular psoriasis (GPP) by administering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. Also provided herein are methods of modulating dysregulated IL-36 signaling in a subject in need thereof and methods of reducing neutrophil, inflammatory dendritic cell (iDC), and/or CD4 T cell accumulation in a subject in need thereof, said methods, include dministering an effective amount of a Chemokine Receptor 6 (CCR6) antagonist and/or a C-X-C motif chemokine receptor 2 (CXCR2) antagonist. In some embodiments, the CCR6 and/or CXCR2 antagonist has the formula: