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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11684050 B1

PDFFull Text
Date of Patent:
Jun. 27, 2023

Filed:

Nov. 04, 2019

Non-human animals having a humanized programmed cell death 1 gene

Applicant:

Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

Elena Burova, Mount Kisco, NY (US);

Alexander O. Mujica, Elmsford, NY (US);

Ka-Man Venus Lai, Seattle, WA (US);

Andrew J. Murphy, Croton-on-Hudson, NY (US);

Assignee:

Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);

Attorneys:

Scully, Scott, Murphy & Presser, P.C.

Casey Donahoe

Primary Examiner:

Shin Lin Chen

Int. Cl.
CPC ...
A01K 67/027 (2006.01); G01N 33/00 (2006.01); A61K 49/00 (2006.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); C07K 16/28 (2006.01); C07K 14/47 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A61K 49/0008 (2013.01); C07K 14/4747 (2013.01); C07K 16/2803 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5038 (2013.01); A01K 2207/15 (2013.01); A01K 2217/05 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C07K 14/435 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/57 (2013.01); G01N 2333/70503 (2013.01); G01N 2500/10 (2013.01);
Abstract

Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals, in some embodiments, comprise a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).

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Quick Actions:

Burova, Elena. (2023). Non-human animals having a humanized programmed cell death 1 gene (U.S. Patent No. 11684050). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11684050

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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