The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 27, 2023
Filed:
Nov. 04, 2019
Applicant:
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Inventors:
Elena Burova, Mount Kisco, NY (US);
Alexander O. Mujica, Elmsford, NY (US);
Ka-Man Venus Lai, Seattle, WA (US);
Andrew J. Murphy, Croton-on-Hudson, NY (US);
Assignee:
Regeneran Pharmaceuticals, Inc., Tarrytown, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); G01N 33/00 (2006.01); A61K 49/00 (2006.01); C12Q 1/6886 (2018.01); G01N 33/50 (2006.01); C07K 16/28 (2006.01); C07K 14/47 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0278 (2013.01); A61K 49/0008 (2013.01); C07K 14/4747 (2013.01); C07K 16/2803 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5038 (2013.01); A01K 2207/15 (2013.01); A01K 2217/05 (2013.01); A01K 2217/072 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); C07K 14/435 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/57 (2013.01); G01N 2333/70503 (2013.01); G01N 2500/10 (2013.01);
Abstract
Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals, in some embodiments, comprise a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).