The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2023

Filed:

Dec. 30, 2019
Applicant:

Repligen Corporation, Waltham, MA (US);

Inventors:

Michael Bransby, Altadena, CA (US);

Derek Carroll, Los Angeles, CA (US);

Philip Yuen, Long Beach, CA (US);

Assignee:

Repligen Corporation, Waltham, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 1/12 (2006.01); C12M 3/00 (2006.01); B01D 69/08 (2006.01); B01D 63/04 (2006.01); C12M 1/00 (2006.01); B01D 71/26 (2006.01);
U.S. Cl.
CPC ...
C12M 25/10 (2013.01); B01D 63/04 (2013.01); B01D 69/081 (2013.01); B01D 71/26 (2013.01); C12M 21/08 (2013.01); C12M 29/10 (2013.01); B01D 2239/0428 (2013.01); B01D 2239/1216 (2013.01); B01D 2239/1225 (2013.01);
Abstract

This disclosure relates to the use of a hydrophobic hollow fiber filter for the filtration of cell cultures and other biological perfusions, due to its resistance to fouling, as well as the ability to filter solutions with a high solid content. A hydrophobic hollow fiber filter may be used within a filter housing in conjunction with a process vessel and a traditional separation system. When the system is used with alternating tangential flow or tangential flow filtration, the hydrophobic hollow fiber filter results in more effective filtration of the filtrate, leading to greater concentration of the retentate, even in solution containing high levels of solids.


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