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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11680086 B1

PDFFull Text
Date of Patent:
Jun. 20, 2023

Filed:

Apr. 18, 2017

Lipopeptide for potently inhibiting hiv, derivative thereof, pharmaceutical composition thereof and use thereof

Applicants:

Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, CN;

Shanxi Kangbao Biological Product Co., Ltd., Changzhi, CN;

Inventors:

Yuxian He, Beijing, CN;

Huihui Chong, Beijing, CN;

Yuanmei Zhu, Beijing, CN;

Assignees:

Shanxi Kangbao Biological Product Co., Ltd., Changzhi, CN;

Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, CN;

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Agnieszka Boesen

Int. Cl.
CPC ...
A61K 47/02 (2006.01); C07K 14/005 (2006.01); C07K 14/16 (2006.01); A61K 47/54 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/162 (2013.01); A61K 47/542 (2017.08); A61K 47/545 (2017.08); A61K 47/554 (2017.08); A61K 38/00 (2013.01);
Abstract

The present application relates to a lipopeptide for potently inhibiting HIV, a derivative thereof, or a pharmaceutical composition thereof, and use thereof. The lipopeptide is the following a) or b): a) a lipopeptide formed by linking a polypeptide having an antiviral activity to a lipophilic compound linked to the carboxyl-terminus of the polypeptide; or b) a lipopeptide formed by linking a polypeptide having an antiviral activity to a terminal protecting group and a lipophilic compound linked to the carboxyl-terminus of the polypeptide, wherein the terminal protecting group is an amino-terminal protecting group and/or a carboxyl-terminal protecting group, the polypeptide has a sequence of 28 amino acid residues, corresponding to amino acids at positions of 127-154 of the sequence of gp41 from HIV-1 strain HXB2. The anti-HIV activity of the lipopeptide of the present invention is higher than that of T-20 by several thousands of times or even tens of thousands of times, and is also significantly higher than that of the anti-HIV lipopeptides such as C34-Chol, LP-19 and the like.

Find Patent Forward Citations

He, Yuxian. (2023). Lipopeptide for potently inhibiting hiv, derivative thereof, pharmaceutical composition thereof and use thereof (U.S. Patent No. 11680086). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11680086

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