The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
Feb. 14, 2022
Northwest A&f University, Xianyang, CN;
Jiangjiang Tang, Xianyang, CN;
Zhaoyuan Bian, Xianyang, CN;
Lanfang Huang, Xianyang, CN;
Bo Ren, Xianyang, CN;
Ping Xiang, Xianyang, CN;
Jinming Gao, Xianyang, CN;
NORTHWEST A & F UNIVERSITY, Xianyang, CN;
Abstract
Disclosed are 3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives, a preparation method and use thereof, and a drug for the treatment of Alzheimer's disease, which relates to the technical field of preparation of acetophenone oxime ether compounds. The (Z)-3,4-methylenedioxyphenylimidazolylethanonexime ether derivatives provided by the present disclosure show a significant effect on the inhibition of NO production, with an ECof 2.07-5.41 μmol/L. Compared with the positive control group of quercetin (with an ECof 9.56 μmol/L) and oxiconazole (with an ECof 13.5 μmol/L), the inhibitory effect is stronger without significant cytotoxicity (cell viability >90%), which can be used to prepare drugs for the treatment of Alzheimer's disease.