The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
Jan. 04, 2019
Applicant:
Desentum Oy, Espoo, FI;
Inventors:
Juha Rouvinen, Espoo, FI;
Kristiina Takkinen, Espoo, FI;
Marja-Leena Laukkanen, Espoo, FI;
Merja Niemi, Espoo, FI;
Janne Jänis, Espoo, FI;
Jaana Haka, Espoo, FI;
Assignee:
Desentum Oy, Espoo, FI;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/35 (2006.01); A61P 37/08 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
A61K 39/35 (2013.01); A61P 37/08 (2018.01); C07K 14/47 (2013.01);
Abstract
The present invention relates to specific modified Equ c 1 polypeptides and to the use of such polypeptides as hypoallergens for desensitizing against horse allergy. Particularly, the present invention provides a recombinant hypoallergenic Equ c 1 polypeptide comprising at least two amino acid modifications compared to a corresponding wild type Equ c 1 allergen, wherein the recombinant hypoallergenic polypeptide activates release of histamine from basophils to a degree less than the wild type allergen.