The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 20, 2023

Filed:

May. 22, 2019
Applicant:

Guangzhou Henovcom Bioscience Co., Ltd., Guangzhou, CN;

Inventors:

Jiancun Zhang, Guangzhou, CN;

Qingan Zou, Guangzhou, CN;

Yanwei Chen, Guangzhou, CN;

Ning Kang, Guangzhou, CN;

Lijun Zhang, Guangzhou, CN;

Yang Hu, Guangzhou, CN;

Jufu Zhang, Guangzhou, CN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/433 (2006.01); A61K 31/438 (2006.01); A61K 31/454 (2006.01); A61K 31/499 (2006.01); A61K 31/4995 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); C07D 513/04 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01); A61K 31/433 (2013.01); A61K 31/438 (2013.01); A61K 31/454 (2013.01); A61K 31/499 (2013.01); A61K 31/4995 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01);
Abstract

Provided are novel heteroaromatic compound as an Autotaxin inhibitor, a pharmaceutical composition comprising the compound, and a use thereof in a treatment of a disease with a pathological feature of Autotaxin overexpression in a mammal, wherein the compound is according to formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, tautomer, nitrogen oxide, metabolite, prodrug, or mixture thereof; wherein each of R, Ar, Ar, Ar, W, Y, Z, and Cy is defined in the present disclosure.


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