The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 20, 2023
Filed:
May. 30, 2019
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Judith Varner, La Jolla, CA (US);
Michael C. Schmid, West Kirby, GB;
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/427 (2006.01); A61P 35/00 (2006.01); A61K 31/7068 (2006.01); A61K 39/395 (2006.01); A61K 49/00 (2006.01); C12N 15/113 (2010.01); C12Q 1/6886 (2018.01);
U.S. Cl.
CPC ...
A61K 31/427 (2013.01); A61K 31/7068 (2013.01); A61K 39/3955 (2013.01); A61K 49/0008 (2013.01); A61P 35/00 (2018.01); C12N 15/1138 (2013.01); C12Q 1/6886 (2013.01); C12N 2310/141 (2013.01); C12N 2320/31 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present invention is based on the finding that CD11b signaling inhibits immune suppression, modulates neovascularization and promotes anti-tumor immune responses in models of murine and human cancer. As such, provided herein are methods of treating cancer using an antibody, protein or small molecule that modulates CD11b activity or expression. Also provided are methods of identifying cancer that is amenable to such treatment and/or increasing susceptibility of cancer cells to treatment with a chemotherapeutic agent.