The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Aug. 03, 2018
The Johns Hopkins University, Baltimore, MD (US);
Asclepix Therapeutics, Inc., Baltimore, MD (US);
Niranjan Pandey, Baltimore, MD (US);
Aleksander S. Popel, Baltimore, MD (US);
Jordan J. Green, Baltimore, MD (US);
Adam Mirando, Baltimore, MD (US);
The Johns Hopkins University, Baltimore, MD (US);
AsclepiX Therapeutics, Inc., Baltimore, MD (US);
Abstract
The present invention in various aspects and embodiments involves pharmaceutical compositions prepared by contacting a candidate α- or β-integrin-binding molecule, or panel thereof, with an integrin heterodimer, and quantifying heterodimer disruption by the candidate molecule. An integrin-binding molecule, or derivative thereof, that disrupts the integrin heterodimer is selected and is formulated into a pharmaceutical composition for administration to a subject, e.g., who has a disease or disorder related to abnormal vascularization.