The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2023

Filed:

Jul. 06, 2005
Applicants:

Roberto Crea, San Mateo, CA (US);

Arvind Rajpal, San Francisco, CA (US);

Guido Cappuccilli, San Mateo, CA (US);

Randy Shen, Sunnyvale, CA (US);

Toshihiko Takeuchi, Oakland, CA (US);

Inventors:

Roberto Crea, San Mateo, CA (US);

Arvind Rajpal, San Francisco, CA (US);

Guido Cappuccilli, San Mateo, CA (US);

Randy Shen, Sunnyvale, CA (US);

Toshihiko Takeuchi, Oakland, CA (US);

Assignee:

Pfizer Inc., New York, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C40B 40/08 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C40B 40/08 (2013.01); C07K 16/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01);
Abstract

Universal antibody libraries are described which are synthetic and derived from expressed human antibody sequences selected accordingly to certain criteria, for example, that the sequences are derived from naturally-occurring antibodies expressed in response to a certain antigen class (e.g., small molecule, polysaccharide, peptide, or protein) and having CDR regions engineered for optimal diversity. Methods for making and screening such libraries for isolating therapeutics suitable for treating disease are also disclosed.


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