The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2023

Filed:

Oct. 23, 2020
Applicant:

Silver Creek Pharmaceuticals, Inc., San Francisco, CA (US);

Inventors:

Ulrik Bjerl Nielsen, Quincy, MA (US);

Thomas Wickham, Groton, MA (US);

Birgit Schoeberl, Cambridge, MA (US);

Brian Harms, Roslindale, MA (US);

Bryan Linggi, Richland, WA (US);

Matthew Onsum, Jamaica Plain, MA (US);

Byron DeLaBarre, Cambridge, MA (US);

Assignee:

Silver Creek Pharmaceuticals, Inc., San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
B82Y 5/00 (2011.01); C07K 14/475 (2006.01); A61K 47/66 (2017.01); A61K 47/68 (2017.01); C07K 16/46 (2006.01); C07K 14/47 (2006.01); C07K 14/65 (2006.01); A61K 38/00 (2006.01); C07K 16/44 (2006.01); C12N 15/62 (2006.01); A61K 45/06 (2006.01); C07K 14/485 (2006.01);
U.S. Cl.
CPC ...
C07K 16/46 (2013.01); A61K 45/06 (2013.01); A61K 47/66 (2017.08); A61K 47/6811 (2017.08); A61K 47/6891 (2017.08); B82Y 5/00 (2013.01); C07K 14/47 (2013.01); C07K 14/475 (2013.01); C07K 14/485 (2013.01); C07K 14/65 (2013.01); C07K 16/44 (2013.01); C12N 15/62 (2013.01); A61K 38/00 (2013.01); C07K 2317/31 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/80 (2013.01);
Abstract

Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.


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