The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Feb. 27, 2020
Applicants:
Allogene Therapeutics, Inc., South San Francisco, CA (US);
Pfizer Inc., New York, NY (US);
Inventors:
Yi Zhang, Foster City, CA (US);
Thomas John Van Blarcom, Oakland, CA (US);
Siler Panowski, Berkeley, CA (US);
Silvia K. Tacheva-Grigorova, Redwood City, CA (US);
Barbra Johnson Sasu, San Francisco, CA (US);
Assignees:
ALLOGENE THERAPEUTICS, INC., South San Francisco, CA (US);
PFIZER INC., New York, NY (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2809 (2013.01); A61P 35/00 (2018.01); C07K 16/2887 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2319/70 (2013.01);
Abstract
Provided herein are DLL3 binding agents and chimeric antigen receptors (CARs) comprising a DLL3 binding molecule that specifically binds to DLL3; and immune cells comprising these DLL3-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using DLL3-specific CARs, and immune cells comprising DLL3-specific CARs.