The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Feb. 12, 2019
Centre National DE LA Recherche Scientifique, Paris, FR;
Universite DE Montpellier, Montpellier, FR;
Ecole Nationale Superieure DE Chimie DE Montpellier, Montpellier, FR;
Ecole Des Mines D'ales, Ales, FR;
Association Pour LA Recherche ET Le Developpement Des Methodes ET Processus Industriels, Paris, FR;
Yves Yeboue, Montpellier, FR;
Benjamin Gallard, Sarcelles, FR;
Nicolas Le Moigne, Saint Sebastien d'Aigrefeuille, FR;
Frédéric Lamaty, Montpellier, FR;
Jean Martinez, Caux, FR;
Thomas-Xavier Metro, Montpellier, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;
UNIVERSITE DE MONTPELLIER, Montpellier, FR;
ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, Montpellier, FR;
ECOLE DES MINES D'ALES, Ales, FR;
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS, Paris, FR;
Abstract
A continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified, the method including the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-amino acid compound, Ra and Rg are as specified, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.