The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2023
Filed:
Apr. 27, 2018
Zikani Therapeutics, Inc., Watertown, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Andrew G. Myers, Boston, MA (US);
Ziyang Zhang, San Francisco, CA (US);
Takehiro Fukuzaki, Tokyo, JP;
Udara Anulal Premachandra Ilandari Dewage, Waukegan, IL (US);
Senkara Rao Allu, Arlington, MA (US);
Roger B. Clark, Lexington, MA (US);
Jonathan F. Lawrence, Somerville, MA (US);
Wesley Francis Austin, Cambridge, MA (US);
Xiben Li, Lexington, MA (US);
Wenying Wang, Boston, MA (US);
Sushmita D. Lahiri, Lexington, MA (US);
Yoshitaka Ichikawa, Cambridge, MA (US);
Other;
Abstract
Provided are macrolide compounds for the treatment of infectious diseases. The macrolides disclosed herein include 14-membered ketolides and 14-15-membered azaketolides, and may comprise modified sugars which are desosamine analogues. The disclosed macrolides may have a bicyclic structure. Also provided are pharmaceutical compositions and methods of treating infectious diseases, and in particular, disease which results from Gram negative bacteria using the disclosed macrolides. This disclosure additionally provides methods of preparing the macrolides by a strategy that enables late-stage modification of the 6'-position of the sugar moiety, thereby allowing facile access to previously difficult-to-make macrolide compounds.