The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2023

Filed:

Jun. 17, 2021
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Peter W. Glunz, Yardley, PA (US);

Vladimir Ladziata, Ewing, NJ (US);

Indawati De Lucca, Pennington, NJ (US);

George O. Tora, Langhorne, PA (US);

Tarun Kumar Maishal, Bangalore, IN;

Raghuram Tangirala, Bengaluru, IN;

Kamalraj Thiyagarajan, Vellore, IN;

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 417/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 495/04 (2006.01); C07D 519/00 (2006.01); C07D 491/052 (2006.01);
U.S. Cl.
CPC ...
C07D 417/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 491/052 (2013.01); C07D 495/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.


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