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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11673885 B1

PDFFull Text
Date of Patent:
Jun. 13, 2023

Filed:

Apr. 27, 2021

γ-diketones as wnt/β-catenin signaling pathway activators

Applicant:

Biosplice Therapeutics, Inc., San Diego, CA (US);

Inventors:

Sunil Kumar KC, San Diego, CA (US);

David Mark Wallace, San Diego, CA (US);

John Hood, San Diego, CA (US);

Charlene F. Barroga, San Diego, CA (US);

Assignee:

BioSplice Therapeutics, Inc., San Diego, CA (US);

Attorney:

Fish & Richardson P.C.

Primary Examiner:

Golam M Shameem

Int. Cl.
CPC ...
C07D 411/06 (2006.01); C07D 213/50 (2006.01); C07D 317/46 (2006.01); C07D 319/16 (2006.01); C07D 327/06 (2006.01); C07D 339/08 (2006.01); C07D 401/06 (2006.01); C07D 405/06 (2006.01); C07D 409/06 (2006.01); C07D 263/56 (2006.01); C07D 311/58 (2006.01); C07D 317/54 (2006.01); C07D 319/18 (2006.01); C07D 231/56 (2006.01); C07D 333/54 (2006.01); C07D 235/06 (2006.01); C07D 407/06 (2006.01); C07D 413/06 (2006.01); C07D 307/80 (2006.01); A61P 25/00 (2006.01);
U.S. Cl.
CPC ...
C07D 411/06 (2013.01); A61P 25/00 (2018.01); C07D 213/50 (2013.01); C07D 231/56 (2013.01); C07D 235/06 (2013.01); C07D 263/56 (2013.01); C07D 307/80 (2013.01); C07D 311/58 (2013.01); C07D 317/46 (2013.01); C07D 317/54 (2013.01); C07D 319/16 (2013.01); C07D 319/18 (2013.01); C07D 327/06 (2013.01); C07D 333/54 (2013.01); C07D 339/08 (2013.01); C07D 401/06 (2013.01); C07D 405/06 (2013.01); C07D 407/06 (2013.01); C07D 409/06 (2013.01); C07D 413/06 (2013.01);
Abstract

The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

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