The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2023

Filed:

Jan. 22, 2020
Applicants:

Biocompatibles Uk Limited, Surrey, GB;

The United States of America, As Represented BY the Secretary Department of Health and Human Service, Bethesda, MD (US);

Inventors:

Matthew R. Dreher, West Conshohocken, PA (US);

Bradford J. Wood, Bethesda, MD (US);

Ayele H. Negussie, Bethesda, MD (US);

Andrew Lennard Lewis, Surrey, GB;

Yiqing Tang, Surrey, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/00 (2006.01); A61K 49/04 (2006.01); C08F 116/06 (2006.01); C08L 29/04 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61K 49/0442 (2013.01); A61K 49/0438 (2013.01); A61K 49/0476 (2013.01); A61K 49/0485 (2013.01); C08F 116/06 (2013.01); C08L 29/04 (2013.01); B82Y 5/00 (2013.01);
Abstract

This invention concerns imageable, radiopaque embolic beads, which are particularly useful for monitoring embolization procedures. The beads comprise iodine containing compounds which are covalently incorporated into the polymer network of a preformed hydrogel bead. The beads are prepared by activating pre-formed hydrogel beads towards nucleophilic attack and then covalently attaching iodinated compounds into the polymer network. The radiopaque beads may be loaded with chemotherapeutic agents and used in methods of embolizing hyperplastic tissue or solid tumors.


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