The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2023

Filed:

May. 24, 2013
Applicant:

Camurus Ab, Lund, SE;

Inventors:

Catalin Nistor, Lund, SE;

Markus Johnsson, Lund, SE;

Fredrik Tiberg, Lund, SE;

Assignee:

CAMURUS AB, Lund, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61K 38/08 (2019.01); A61K 9/00 (2006.01); A61K 38/31 (2006.01); C07K 5/00 (2006.01); C07K 7/00 (2006.01); C07K 16/00 (2006.01); C07K 17/00 (2006.01); A61K 38/04 (2006.01); A61K 47/10 (2017.01); A61K 47/14 (2017.01); A61K 47/24 (2006.01); A61K 31/4045 (2006.01); A61K 9/127 (2006.01); C07K 7/64 (2006.01); A61K 47/18 (2017.01);
U.S. Cl.
CPC ...
A61K 38/12 (2013.01); A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/1274 (2013.01); A61K 31/4045 (2013.01); A61K 38/08 (2013.01); A61K 38/31 (2013.01); A61K 47/10 (2013.01); A61K 47/14 (2013.01); A61K 47/24 (2013.01); C07K 7/64 (2013.01); A61K 47/183 (2013.01);
Abstract

The present invention relates to compositions forming a low viscosity mixture of: a) 20-50 wt. % of at least one diacyl glycerol; b) 20-54 wt. % of at least one phosphatidyl choline (PC); c) 5-15 wt. % of at least one biocompatible, organic mono-alcoholic solvent; d) 1 to 20 wt. % polar solvent e) 5 to 150 mg/ml of at least one peptide somatostatin receptor agonist comprising pasireotide; f) optionally at least one antioxidant; wherein the ratio of components a:b is in the range 40:60 to 54:46; wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with excess aqueous fluid. The invention further relates to methods of treatment comprising administration of such compositions, and to pre-filled administration devices and kits containing the formulations.


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