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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11672816 B1

PDFFull Text
Date of Patent:
Jun. 13, 2023

Filed:

Mar. 19, 2019

Antisense oligonucleotides and uses thereof

Applicants:

Fundació Centre DE Regulació Genòmica, Barcelona, ES;

Institució Catalana DE Recerca I Estudis Avançats, Barcelona, ES;

Fundación Del Sector Público Estatal Centro Nacional DE Investigaciones Oncológicas Carlos Iii (F.s.p. Cnio), Madrid, ES;

Inventors:

Jordi Hernández Ribera, Barcelona, ES;

Juan Alberto Valcárcel Juárez, Barcelona, ES;

Elias Bechara, Barcelona, ES;

Manuel Serrano Marugán, Tres Cantos, ES;

Miguel Rovira Del Olmo, Madrid, ES;

Pablo José Fernández Marcos, Las Rozas, ES;

Assignees:

INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS, Barcelona, ES;

FUNDACIÓ CENTRE DE REGULACIÓ GENÒMICA, Barcelona, ES;

FUNDACIÓN DEL SECTOR PÚBLICO ESTATAL CENTRO NACION, Barcelona, ES;

Attorney:

Dinsmore & Shohl LLP

Primary Examiner:

Kimberly Chong

Int. Cl.
CPC ...
C07H 21/04 (2006.01); A61K 31/712 (2006.01); A61P 35/00 (2006.01); A61K 9/00 (2006.01); A61K 31/7125 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 31/712 (2013.01); A61K 9/0019 (2013.01); A61K 31/7125 (2013.01); A61P 35/00 (2018.01); C12N 15/113 (2013.01);
Abstract

Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Find Patent Forward Citations

Hernández Ribera, Jordi. (2023). Antisense oligonucleotides and uses thereof (U.S. Patent No. 11672816). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11672816

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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