The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Jul. 30, 2020
Applicant:
Brown University, Providence, RI (US);
Inventors:
Jack A. Elias, Providence, RI (US);
Chun Geun Lee, Woodbridge, CT (US);
Chuan Hua He, Madison, CT (US);
Bing Ma, Branford, CT (US);
Suchitra Kamle, Providence, RI (US);
Chang-Min Lee, Warwick, RI (US);
Assignee:
Brown University, Providence, RI (US);
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01); A61P 35/04 (2006.01); A61K 45/06 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07K 16/2803 (2013.01); C07K 16/2839 (2013.01); A61K 2039/505 (2013.01); A61K 2300/00 (2013.01); C07K 2317/34 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01);
Abstract
It is demonstrated herein that inhibitors of immune checkpoints and CHI3L1 are synergistic. Accordingly, described herein are methods and compositions relating to combinatorial therapies for cancer, e.g., comprising an inhibitor of CHI3L1; and an inhibitor of an immune checkpoint protein. In some embodiments, the CHI3L1 inhibitor can be an antibody or antibody reagent as described herein.