The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Aug. 28, 2020
Ngm Biopharmaceuticals, Inc., South San Francisco, CA (US);
Kalyani Mondal, San Mateo, CA (US);
Betty Chan Li, Millbrae, CA (US);
Yu Chen, Foster City, CA (US);
Taruna Arora, Palo Alto, CA (US);
Hugo Matern, San Mateo, CA (US);
Wenyan Shen, Redwood City, CA (US);
NGM Biopharmaceuticals, Inc., South San Francisco, CA (US);
Abstract
The present disclosure provides binding proteins, such as antibodies, and binding fragments thereof, that bind beta klotho, including human beta klotho, and exemplary specific sequences of their complementarity determining regions, variable regions, heavy chains, and light chains. The present disclosure also provides method of making the antibody or fragment thereof and methods of their use, including, in activating beta-klotho/FGF receptor complex, inducing FGF19-like and/or FGF21-like signaling, improving glucose and lipid metabolism, and treatment of nonalcoholic steatohepatitis.