The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Mar. 16, 2022
Cytomx Therapeutics, Inc., South San Francisco, CA (US);
Sayantan Mitra, Mountain View, CA (US);
Nicole G. Lapuyade, San Francisco, CA (US);
Hikmat Haizar Assi, San Pablo, CA (US);
Madan M. Paidhungat, San Francisco, CA (US);
Dylan L. Daniel, San Francisco, CA (US);
Erwan Le Scolan, San Francisco, CA (US);
Walter A. Bogdanoff, Rio Vista, CA (US);
Na Cai, San Mateo, CA (US);
Hsin Wang, San Mateo, CA (US);
Alexey Yevgenyevich Berezhnoy, Burlingame, CA (US);
CytomX Therapeutics, Inc., South San Francisco, CA (US);
Abstract
Provided herein are activatable cytokine constructs that include: (a) a first monomer construct comprising a first peptide mask (PM1), a third cleavable moiety (CM3), a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein the CM1 is positioned between the CP1 and the DD1, and the CM3 is positioned between the PM1 and CP1; and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), where the CM2 is positioned between the CP2 and the DD2, where: the DD1 and the DD2 bind each other; and where the ACC is characterized by a reduction in at least one activity of the CP1 and/or CP2 as compared to a control level of the at least one activity of the CP1 and/or CP2.