The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Feb. 19, 2018
Fresenius Kabi Oncology Limited, New Delhi, IN;
Maneesh Kumar Pandey, Haryana Gurgaon, IN;
Raj Narayan Tiwari, Haryana Gurgaon, IN;
Sonu Shukla, Haryana Gurgaon, IN;
Sarbjot Singh Sokhi, Haryana Gurgaon, IN;
Govind Singh, Haryana Gurgaon, IN;
Saswata Lahiri, Haryana Gurgaon, IN;
Walter Cabri, Cassina de' Pecchi, IT;
Fresenius Kabi Oncology Ltd., New Delhi, IN;
Abstract
The present invention relates to an improved process for the preparation of a compound of formula (I), wherein PGmay be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), benzylidene, methanesulfonyl (Mesyl), toluene sulfonyl (Tosyl) or acyl; its isolation as solid and use for the preparation of the compound of formula (IV), in particular the compound of formula (IV) i.e. [(1R)-3-methyl-1[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl) amino]propyl]amino]butyl] boronic acid with more than 99.95% chiral purity, as measured by HPLC.