The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Feb. 27, 2020
Applicant:
Lunella Biotech, Inc., Ottawa, CA;
Inventors:
Michael P. Lisanti, Manchester, GB;
Federica Sotgia, Manchester, GB;
Assignee:
LUNELLA BIOTECH, INC., Ontario, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 209/42 (2006.01); G16C 20/50 (2019.01); C07D 265/36 (2006.01); C07D 417/12 (2006.01); C40B 30/06 (2006.01); C40B 40/14 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 209/42 (2013.01); C07D 265/36 (2013.01); C07D 417/12 (2013.01); C40B 30/06 (2013.01); C40B 40/14 (2013.01); G16C 20/50 (2019.02);
Abstract
The present disclosure relates to compounds that bind to at least one of ACAT1/2 and OXCT1/2 and inhibit mitochondrial ATP production, referred to herein as mitoketoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoketoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoketoscins to provide anti-aging benefits. Specific mitoketoscin compounds are also disclosed.