The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Dec. 07, 2018
Sichuan Kelun-biotech Biopharmaceutical Co., Ltd., Chengdu, CN;
Jinming Liu, Chengdu, CN;
Jiaqiang Cai, Chengdu, CN;
Yongyong Wu, Chengdu, CN;
Wei Yin, Chengdu, CN;
Lichun Wang, Chengdu, CN;
Jingyi Wang, Chengdu, CN;
SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD., Chengdu, CN;
Abstract
The present invention generally relates to an isoxazole derivative, a preparation therefor, and a use thereof. In particular, the present invention provides a farnesoid X receptor (FXR) agonist compound, and a stereoisomer, a tautomer, a polymorph, a solvate (e.g., a hydrate), a pharmaceutically acceptable salt, an ester, a metabolite, and an N-oxide, and the chemically protected forms and prodrugs thereof. The present invention further provides a preparation method for the compound, an intermediate thereof, and a pharmaceutical composition and kit containing the same and used thereof for treating FXR-mediated diseases or conditions.