The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Dec. 07, 2021
Astrazeneca Ab, Södertälje, SE;
Mitsubishi Tanabe Pharma Corporation, Osaka, JP;
Kenneth Lars Granberg, Gothenburg, SE;
Shigeki Sakamaki, Osaka, JP;
Ryuichi Fuchigami, Osaka, JP;
Yasuki Niwa, Osaka, JP;
Masakazu Fujio, Osaka, JP;
Hans Fredrik Bergström, Göthenburg, SE;
Stig Jonas Boström, Göthenburg, SE;
AstraZeneca AB, , SE;
MITSUBISHI TANABE PHARMA CORPORATION, Osaka, JP;
Abstract
The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where A, U, V, W, X, Y, Z, R, R, R, Rand Rhave the meanings defined herein. Such compounds are modulators of RXFP1 and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions including heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. The specification further relates to compositions comprising such compounds, intermediates useful in processes for preparing such compounds, and processes for preparing such compounds using such intermediates.