The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Nov. 23, 2021
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Muthiah Manoharan, Cambridge, MA (US);
Kallanthottathil G. Rajeev, Cambridge, MA (US);
Jayaprakash K. Nair, Cambridge, MA (US);
Martin Maier, Cambridge, MA (US);
Assignee:
ALNYLAM PHARMACEUTICALS, INC., Cambridge, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/28 (2006.01); A61K 31/7004 (2006.01); A61K 31/7052 (2006.01); A61K 31/70 (2006.01); A61K 47/60 (2017.01); A61K 47/54 (2017.01); C07H 21/02 (2006.01); A61K 31/7088 (2006.01); A61K 31/713 (2006.01); A61K 47/16 (2006.01); A61K 47/22 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/28 (2013.01); A61K 31/70 (2013.01); A61K 31/7004 (2013.01); A61K 31/7052 (2013.01); A61K 31/7088 (2013.01); A61K 31/713 (2013.01); A61K 47/16 (2013.01); A61K 47/22 (2013.01); A61K 47/543 (2017.08); A61K 47/549 (2017.08); A61K 47/60 (2017.08); C07H 21/02 (2013.01); A61K 48/00 (2013.01); Y02A 50/30 (2018.01); Y02P 20/55 (2015.11);
Abstract
The present invention provides a modified RNAi agent comprising a sense strand and an antisense strand, wherein the antisense strand targets an HBV mRNA; all of the nucleotide sugars of the RNAi agent are 2'-modified; and at least one of the sense and antisense strands is conjugated to at least one targeting ligand that comprises two or more building blocks connected to a biantennary or triantennary branched linker, optionally via one or more linking groups.