The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 06, 2023

Filed:

Sep. 29, 2020
Applicant:

Albany Medical College, Albany, NY (US);

Inventors:

Karsten Hazlett, East Berne, NY (US);

Kristen M. Tummillo, Union, NJ (US);

Edmund J. Gosselin, Delanson, NY (US);

Assignee:

ALBANY MEDICAL COLLEGE, Albany, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/02 (2006.01); C12N 15/87 (2006.01); A61K 38/17 (2006.01); A61K 38/16 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/02 (2013.01); A61K 38/164 (2013.01); A61K 38/1725 (2013.01); C12N 15/87 (2013.01); A61K 2039/55516 (2013.01); C12N 2310/3517 (2013.01); C12N 2800/10 (2013.01);
Abstract

An approach for modifying multiple types of bacteria to produce surface modifications that enhance the immunologic response when used as a vaccine. A series of plasmids (pYF, pYFC, pYFP, pSF, pSPF, and pSCF) may be used to transform bacteria which then produce surface-exposed ligands that bind to complement receptors on antigen presenting cells. When modified bacteria are used as a vaccine, the vaccine recipients produce significantly higher titers of specific antibodies and are better protected against challenges from the disease-causing bacteria.


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