The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Sep. 24, 2020
Auburn University, Auburn, AL (US);
Edward Via College of Osteopathic Medicine—auburn, Auburn, AL (US);
Tatiana I. Samoylova, Auburn, AL (US);
Alexandre M. Samoylov, Auburn, AL (US);
Kenny V. Brock, Auburn, AL (US);
Anna M. Cochran, Auburn, AL (US);
James W. Gillespie, Auburn, AL (US);
Auburn University, Auburn, AL (US);
Edward Via College of Osteopathic Medicine—Auburn, Auburn, AL (US);
Abstract
Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.