The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
Apr. 18, 2018
Applicant:
Newbio Therapeutics, Inc., Shanghai, CN;
Inventors:
Deqiang An, Shanghai, CN;
Nianhe Han, Shanghai, CN;
Peng Zhu, Shanghai, CN;
Di Zeng, Shanghai, CN;
Baoxiang Wang, Shanghai, CN;
Huali Li, Shanghai, CN;
Chun Yang, Shanghai, CN;
Assignee:
NewBio Therapeutics, Inc., Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 207/452 (2006.01); C07D 403/14 (2006.01); C07K 7/06 (2006.01); A61K 38/07 (2006.01); A61K 47/65 (2017.01); A61K 45/00 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/00 (2006.01); A61K 47/68 (2017.01);
U.S. Cl.
CPC ...
A61K 38/07 (2013.01); A61K 47/65 (2017.08); A61K 47/6849 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07D 403/14 (2013.01);
Abstract
The present invention is directed to tetramaleimide linkers and use thereof, more specifically to the compounds represented by formula I and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from the tetramaleimide linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula I is the same as that in the description.