The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 06, 2023
Filed:
May. 07, 2019
The Scripps Research Institute, La Jolla, CA (US);
William R. Roush, Jupiter, FL (US);
Derek R. Duckett, Jupiter, FL (US);
Andrii Monastyrskyi, Jupiter, FL (US);
THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC., Gainseville, FL (US);
THE UNIVERSITY OF FLORIDA BOARD OF TRUSTEES, Gainesville, FL (US);
Abstract
The invention provides compounds and methods of inhibiting a cyclin-dependent kinase, comprising contacting the cyclin-dependent kinase and an effective amount or concentration of a compound of formula (I) wherein variables are as defined herein. Compounds of formula (I) can be highly selective inhibitors of cyclin-dependent kinases such as CDK12/13, relative to other kinases such as casein kinases, such as CK1δ/ε. Compounds can be used in treatment of cancers, such as breast cancer, brain cancer and ovarian cancer.