The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Jun. 12, 2020
Applicant:
Laboratory Corporation of America Holdings, Burlington, NC (US);
Inventor:
Robert MacNeill, Monroe Township, NJ (US);
Assignee:
Laboratory Corporation of America Holdings, Burlington, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/02 (2006.01); C12N 15/10 (2006.01); G01N 1/40 (2006.01);
U.S. Cl.
CPC ...
G01N 30/02 (2013.01); C12N 15/1017 (2013.01); G01N 1/405 (2013.01); G01N 2030/027 (2013.01); G01N 2560/00 (2013.01);
Abstract
Methods of LC-MS analysis of oligonucleotides free of ion-pairing reagents are disclosed herein. Historically, ion-pairing reagents have been used for acceptable extraction and chromatography prior to mass spectral analysis. The disclosure herein presents methods free of ion-pairing reagents at each stage, from extraction through the LC-MS endpoint. Also disclosed herein are systems for performing these methods.