The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Dec. 13, 2018
Applicants:

National Technology & Engineering Solutions of Sandia, Llc, Albuquerque, NM (US);

The Regents of the University of California, Oakland, CA (US);

Inventors:

Oscar Negrete, Livermore, CA (US);

Jennifer A. Doudna, Berkeley, CA (US);

Steven C. Strutt, Berkeley, CA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 9/22 (2006.01); C12Q 1/6888 (2018.01); A61K 31/7088 (2006.01); A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
C12N 15/11 (2013.01); A61K 31/7088 (2013.01); A61K 38/465 (2013.01); C12N 9/22 (2013.01); C12Q 1/6888 (2013.01); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract

The present invention relates to a CRISPR-Cas based system for targeting nucleic acid sequences. In part, the invention relates to synthetic guiding components for targeting single-stranded sequences, as well as design principles for constructing such components. Also described herein are methods of employing such components, e.g., to repress or activate a desired target within the subject.


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