The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Dec. 03, 2018
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Vamsi K. Mootha, Boston, MA (US);
Xiaoyan Robert Bao, Berkeley, CA (US);
Anupam Patgiri, Cambridge, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/08 (2006.01); A61P 1/00 (2006.01); A61K 35/18 (2015.01); C12N 9/02 (2006.01); C12N 11/16 (2006.01); A61K 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/0065 (2013.01); A61K 35/18 (2013.01); A61P 1/00 (2018.01); C12N 9/0069 (2013.01); C12N 11/16 (2013.01); A61K 9/0019 (2013.01); A61K 38/00 (2013.01); C12Y 111/01006 (2013.01); C12Y 113/12004 (2013.01);
Abstract
Compositions comprising (i) lactate oxidase (LOX) and Catalase (CAT), preferably in a 1:1 molar ratio; or (ii) a fusion polypeptide comprising both LOX and CAT, e.g., LOXCAT, and methods of use thereof for reducing blood lactate levels, increasing blood pyruvate levels, and/or decreasing blood lactate/pyruvate ratio in a subject.