The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Apr. 04, 2018
Applicant:

Southeast University, Nanjing, CN;

Inventors:

Zhen Zhu, Nanjing, CN;

Qiaodan Li, Nanjing, CN;

Dingxin Jin, Nanjing, CN;

Feng Yu, Nanjing, CN;

Yangye Geng, Nanjing, CN;

Assignee:

SOUTHEAST UNIVERSITY, Nanjing, CN;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12M 3/00 (2006.01); B01L 3/00 (2006.01); C12M 3/06 (2006.01); C12M 1/34 (2006.01);
U.S. Cl.
CPC ...
C12M 21/08 (2013.01); B01L 3/50273 (2013.01); C12M 23/16 (2013.01); C12M 41/46 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0864 (2013.01); B01L 2400/0475 (2013.01);
Abstract

A microfluidic chip for culturing and real-time monitoring of multicellular tissues and use method thereof. The chip comprises a glass substrate layer, and a PDMS microchannel layer located on the glass substrate layer, wherein the glass substrate layer comprises a glass substrate, and a plurality of microelectrodes thereon; the PDMS microchannel comprises a plurality of independent microfluidic channels; the microelectrodes on the glass substrate are in one-to-one correspondence with the microfluidic channels in the PDMS microchannel layer; and the microelectrodes are electrically connected to an external circuit. The use method comprises: cell capture, cell or tissue culture, electrical impedance spectroscopy detection, and tissue release.


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