The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2023
Filed:
Aug. 05, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
Andreas Herrmann, Pasadena, CA (US);
Hua Yu, Glendora, CA (US);
Assignee:
City of Hope, Duarte, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); A61K 38/00 (2006.01); A61K 38/14 (2006.01); A61P 35/00 (2006.01); C07K 16/00 (2006.01); C12N 15/11 (2006.01); A61K 47/68 (2017.01); A61K 47/54 (2017.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C07K 16/40 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); A61K 38/00 (2013.01); A61K 38/14 (2013.01); A61K 47/549 (2017.08); A61K 47/6843 (2017.08); A61K 47/6851 (2017.08); A61K 47/6871 (2017.08); A61K 47/6879 (2017.08); A61K 47/6889 (2017.08); A61P 35/00 (2018.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/30 (2013.01); C07K 16/40 (2013.01); C12N 15/11 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/40 (2013.01); C07K 2317/622 (2013.01); C07K 2317/77 (2013.01); C12N 2310/18 (2013.01); C12N 2310/315 (2013.01); C12N 2310/3513 (2013.01);
Abstract
Provided herein are cell penetrating conjugates. The conjugates include non-cell penetrating proteins connected through a phosphorothioate nucleic acid, wherein the phosphorothioate nucleic acid enhances intracellular delivery of the non-cell penetrating proteins. Also provided are methods and kits including the conjugates provided herein.