The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 30, 2023

Filed:

Jun. 15, 2018
Applicant:

Denali Therapeutics Inc., South San Francisco, CA (US);

Inventors:

Jason C. Dugas, South San Francisco, CA (US);

Anastasia Henry, South San Francisco, CA (US);

Sarah Huntwork-Rodriguez, South San Francisco, CA (US);

Michael T. Maloney, South San Francisco, CA (US);

Nathan Moerke, South San Francisco, CA (US);

Ella Negrou, South San Francisco, CA (US);

Xiang Wang, South San Francisco, CA (US);

Assignee:

Denali Therapeutics Inc., South San Francisco, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01); G01N 33/573 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); G01N 33/573 (2013.01); G01N 33/6896 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); G01N 2440/14 (2013.01); G01N 2800/2835 (2013.01); G01N 2800/52 (2013.01);
Abstract

In one aspect, antibodies that specifically bind to a phosphorylated Rab protein are provided. In some embodiments, the antibody is a monoclonal antibody that specifically binds to a phosphorylated human Rab10 protein and recognizes an epitope within or comprising the sequence AGQERFH(pT)ITTSYYR (SEQ ID NO:123). In some embodiments, the antibody is a monoclonal antibody that specifically binds to a phosphorylated human Rab8a protein and recognizes an epitope within or comprising the sequence QERFR(pT)ITTAY (SEQ ID NO:125). Methods and materials for detecting LRRK2 and Rab protein are also provided.


Find Patent Forward Citations

Dugas, Jason. (2023). Phospho-rab antibodies, assays and methods of use thereof (U.S. Patent No. 11661461). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11661461

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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